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SI-5230

Tecovirimat, >98% (HPLC)

CAS No. : 
[869572-92-9]    
MDL No. : 
MFCD11973644
Synonyms : 4-Trifluoromethyl-N-(3,3a,4,4a,5,5a,6,6a-octahydro-1,3-dioxo-4,6-ethenocycloprop(f)isoindol-2(1H)-yl)-benzamide

Price and Availability
Note: This product has been withdrawn from sale for commercial reasons.
Chemical Properties
C19H15F3N2O3 376.34
Solid Not available
For Laboratory research use only, not for drug, household or other uses.
Applications : Tecovirimat is a core protein cysteine protease inhibitor potentially for treatment of smallpox infection. Tecovirimat is a novel antiviral that inhibits the egress of orthopoxviruses by targeting viral p37 protein orthologs. Tecovirimat has shown efficacy in all small animal and nonhuman primate prophylaxis and therapeutic efficacy models of poxvirus-induced disease tested to date.
References : Lindholm D. A. et al.: Clin Infect Dis., 69(12), 2205-2207, 2019; Chan-Tack K. M. et al.: Lancet Infect Dis., 19(6), e221-e224, 2019; Laudisoit A. N. Engl J. Med., 379(21), 2084-2085, 2018; Russo A. T. et al.: J. Infect Dis., 218(9), 1490-1499, 2018; Grosenbach D. W. et al.: N. Engl J. Med., 379(1), 44-53, 2018; Berhanu A. et al.: Antimicrob Agents Chemother., 59(7), 4296-300, 2015.
Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.
Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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Product ID : SI-5230

Product Name : Tecovirimat

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