SynInnova Laboratories Inc.

SI-5344

ZSTK474, >98% (HPLC)

CAS No. :

[475110-96-4]

MDL No. :

MFCD08705334

Synonyms : 4,4'-(6-(2-(Difluoromethyl)-1H-benzo[d]imidazol-1-yl)-1,3,5-triazine-2,4-diyl)dimorpholine

Price and Availability
Pack Size	Price in USD	Quantity	Availability	Shipping Status
5MG	90.00	- +	Back Order	Estimated to Ship on 06.08.2024
10MG	150.00	- +	Back Order	Estimated to Ship on 06.08.2024
50MG	450.00	- +	Back Order	Estimated to Ship on 06.08.2024
100MG	850.00	- +	Back Order	Estimated to Ship on 06.08.2024
250MG	1650.00	- +	Back Order	Estimated to Ship on 06.08.2024

Chemical Properties
Mol. Formula : C₁₉H₂₁F₂N₇O₂	Mol. Weight : 417.42
Appearance : Solid	Melting Point : Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : ZSTK474 inhibits class I PI3K isoforms with IC50 of 37 nM in a cell-free assay, mostly PI3Kδ. ZSTK474 showed potent antitumor activity in vivo against a human cancer xenograft without observable toxicity.

References : Yaguchi S. et al.: J. Natl Cancer Inst., 98(8), 545-556, 2006; Kong D. et al.: Cancer Sci., 98(10), 1638-1642, 2007; Kong D. et al.: Eur J Cancer., 45(5), 857-865, 2009; Marone R. et al.: Mol Cancer Res., 7(4), 601-613, 2009; Yang S. et al. PLoS One 6(10), e26343, 2011; Haruta K. et al.: Inflamm Res., 61(6), 551-562, 2012.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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Product ID : SI-5344

Product Name : ZSTK474

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ZSTK474, >98% (HPLC)

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