[38396-39-3]    

MFCD00243007

Synonyms : 1-Butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide

Applications : Bupivacaine binds to the intracellular portion of voltage-gated sodium channels and blocks sodium influx into nerve cells, used for treating cardiac arrhythmias.

References : Chu C. R. et al.: Arthroscopy 22(7), 693-699, 2006; Sztark F. et al.: Anesthesiology, 88(5), 1340-1349, 1998; Irwin W. et al.: J. Biol Chem., 277(14), 12221-12227, 2002; Zhou W. et al.: Proc Natl Acad Sci U S A, 98(11), 6482-6487, 2001; Zink W. et al.: Anesthesiology 97(3), 710-716; 2002; Butterworth J. F. et al.: Anesthesiology 79(1), 88-95, 1993.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.