[1439901-97-9]    

MFCD30187521

Synonyms : (R)-6-Amino-9-(1-(but-2-ynoyl)pyrrolidin-3-yl)-7-(4-phenoxyphenyl)-7,9-dihydro-8H-purin-8-one hydrochloride; ONO-4059 hydrochloride; GS-4059 hydrochloride

Applications : Tirabrutinib hydrochloride is a selective and novel inhibitor of BTK with IC50 2.2 nM, Tirabrutinib hydrochloride binds to BTK within B cells, thereby preventing B-cell receptor signaling and impeding B-cell development. Tirabrutinib hydrochloride can be used for the treatment of autoimmune disorders and hematological malignancies.

References : Burger J. A. et al.: Curr Hematol Malig Rep., 9(1), 44-49, 2014; Harriet S. Walter S. H. et al.: Blood, 127(4), 411-419, 2016.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.