[943332-08-9]    

Synonyms : 5-((4-Bromo-2-chlorophenyl)amino)-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzo[d]imidazole-6-carboxamide sulfate; AZD6244 sulfate; ARRY-142886 sulfate

Applications : Selumetinib sulfate is a selective, non-ATP-competitive oral MEK1/2 inhibitor, with an IC50 of 14 nM for MEK1. Selumetinib sulfate inhibits ERK1/2 phosphorylation. Selumetinib is being developed for the potential treatment of RAS-driven malignancies.

References : Huynh H. et al.: Mol. Cancer Therapy 6 (1), 138-146, 2007; Garon E. B. et al.: Mol. Cancer Thera., 9 (7), 1985-1994, 2010; Yeh T. C. et al.: Clin Cancer Res., 13 (5), 1576-1583, 2007; Sebolt-Leopold J. S. et al.: Nat Rev Cancer 4(12), 937-47, 2004; Dela Cruz F. S. et al.: Genome Med., 8(1), 116, 2016; Weisberg E. et al.: Clin Cancer Res., 20(21), 5483-95, 2014.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.