[1206801-37-7]    

MFCD26142925

Synonyms : N-(3-Fluoro-4-((1-methyl-6-(1H-pyrazol-4-yl)-1H-indazol-5-yl)oxy)phenyl)-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide dihydrochloride; LY2801653 dihydrochloride

Applications : Merestinib dihydrochloride is a potent, orally bioavailable c-Met inhibitor (Ki=2 nM) with antitumor activities. Merestinib dihydrochloride also has potent activity against MST1R (IC50=11 nM), FLT3 (IC50=7 nM), AXL (IC50=2 nM), MERTK (IC50=10 nM), TEK (IC50=63 nM), ROS1, DDR1/2 (IC50=0.1/7 nM) and MKNK1/2 (IC50=7 nM).

References : Yan S. B. et al.: Invest New Drugs 31(4), 833-44, 2013; Barat S. et al.: Mol Carcinog 55(12), 2037-2050, 2016.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.