[1616345-45-9]    

[2756-87-8] of the unlabelled compound

Synonyms : (2E)-2-Butenedioic acid 1-methyl ester-d₅; (E)-2-Butenedioic acid monomethyl ester-d₅; Fumaric acid methyl ester-d₅; Methyl hydrogen fumarate-d₅; Monomethyl fumarate-d₅

Applications : Fumaric acid monomethyl ester-d5 is the isotope labelled analog of Fumaric acid monomethyl ester. It is one of the most bioactive anti-psoriatic fumaric acid ester metabolite. Also it is a potent nicotinic acid receptor agonist. It has also been shown to selectively stimulate of T helper 2 cytokine response. It is also the active metabolite of Dimethyl fumarate, a compound that is used as a treatment for the relapsing forms of multiple sclerosis and psoriasis.

References : De Jong. R. et al.: Eur. J. Immunol., 26, 2067, 1996; Litjens. N.H.R. et al.: Br. J. Dermatol., 154, 211, 2006; Schimrigk. S. et al.: Eur. J. Neurol., 13, 604, 2006; Tang, H. et al.: Biochem. Biophys. Res. Comm., 375, 562, 2008.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.