[1129540-33-5]    

Synonyms : NSC-125973-d₅; Taxol-d₅

Applications : Paclitaxel-d5 is a deuterium labelled version of Paclitaxel, which is a naturally occurring antineoplastic agent and stabilizes tubulin polymerization. Paclitaxel can cause both mitotic arrest and apoptotic cell death. Tubulin depolymerization inhibitor. It is used to treat a number of types of cancers.This includes ovarian cancer, breast cancer, lung cancer, Kaposi sarcoma, cervical cancer, and pancreatic cancer.

References : Wang J. et al.: Anticancer Drugs., 14(1), 13-19, 2003; Sun R.G et al.: Gen Physiol Biophys, 31(1), 1-10, 2012; Zhang X. H. et al.: Cancer Lett., 322(2), 213-222, 2012; Chang J. et al. Breast Cancer Res Treat.. 134(3), 969-80, 2012.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.