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SL-5004

Ethyl (S)-2-hydroxy-3-methoxy-3,3-diphenylpropionate, >98%

Synonyms : (S)-2-Hydroxy-3-methoxy-3,3-diphenylpropionic acid ethyl ester

Price and Availability
Pack Size Price in USD Quantity Availability Shipping Status
25MG180.00 Back Order Estimated to Ship on 05.27.2024
250MG1280.00 Back Order Estimated to Ship on 05.27.2024
Chemical Properties
C18H20O4 300.35
White to Off-white solid Not available
For Laboratory research use only, not for drug, household or other uses.
Applications : This is an advanced key intermediate in the preparation of Ambrisentan, which is a highly selective antagonist of the endothelin-1 type A receptor (ETAR), used in the treatment of pulmonary arterial hypertension (PAH).
References : Weiss J. et al.: Eur J Pharmacol, 660(2-3), 298-304, 2011; Yokoyama Y. et al.: Biol Pharm Bull, 37(3), 461-465, 2014; Weiss J. et al.: Biochem Pharmacol, 85(2), 265-273, 2013; Osano A. et al.: J. Pharmacol Sci, 124(1), 86-91, 2014; Buckley M. S. et al.: Expert Opin Drug Metab Toxicol, 7(3), 371-380, 2011.
Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.
Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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Product ID : SL-5004

Product Name : Ethyl (S)-2-hydroxy-3-methoxy-3,3-diphenylpropionate

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