[35202-54-1]    

MFCD01846132

Synonyms : 3,4-Dimethoxybicyclo[4.2.0]octa-1(6),2,4-triene-7-carbonitrile

Applications : This is an advanced key intermediate in the preparation of Ivabradine and related analogs, which is an orally bioavailable, hyperpolarization-activated, cyclic nucleotide-gated (HCN) channel blocker, used for the symptomatic management of stable heart-related chest pain and heart failure not fully managed by beta blockers.

References : Thollon C. et al.: Br. J. Pharmacol.,112(1), 37-42, 1994; Fang Y. et al.: J. Cardiovasc Pharmacol., 59(3), 260-7, 2012; Kroller-Schon S. et al.: Basic Res Cardiol.,106(6), 1147-58, 2011.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.