[289472-80-6]    

Synonyms : (S)-N-(1-Amino-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide; Bortezomib USP impurity B

Applications : This is an impurity of Bortezomib, which is a potent 20S proteasome inhibitor. It exhibits favorable selectivity towards tumor cells over normal cells. Bortezomib inhibits NF-κB and induces ERK phosphorylation to suppress cathepsin B and inhibit the catalytic process of autophagy in ovarian cancer and other solid tumors.

References : Adams J. et al.: Cancer Res., 59(11), 2615-2622, 1999; Boccadoro M. et al.: Cancer Cell Int., 5(1), 18, 2005; LeBlanc R. et al.: Cancer Res., 62(17), 4996-5000, 2002; Stein R. L. et al.: Biochemistry, 35(13), 3899-3908, 1996; Hideshima T. et al.: Cancer Res., 61(7), 3071-3076, 2001, Mohammad A Shahshahan et al.: Am J. Cancer Res., 1(7), 913-24, 2011.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.