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SI-5138

IMD-0354, >98% (HPLC)

CAS No. : 
[978-62-1]    
MDL No. : 
MFCD00218820
Synonyms : N-(3,5-Bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide

Price and Availability
Pack Size Price in USD Quantity Availability Shipping Status
10MG80.00 Back Order Estimated to Ship on 05.19.2024
25MG160.00 Back Order Estimated to Ship on 05.19.2024
50MG220.00 Back Order Estimated to Ship on 05.19.2024
100MG300.00 Back Order Estimated to Ship on 05.19.2024
250MG650.00 Back Order Estimated to Ship on 05.19.2024
Chemical Properties
C15H8ClF6NO2 383.67
Solid Not available
For Laboratory research use only, not for drug, household or other uses.
Applications : IMD-0354 is a selective IKKβ inhibitor which inhibits NF-κB activity. IMD-0354 inhibits TNF-α induced NF-κB transcription activity with an IC50 of 1.2 uM. IMD-0354 had been in phase I clinical trials for the treatment of atopic dermatitis.
References : Tanaka A. et al.: Blood 105(6), 2324-31, 2005; Li Y. R. et al. Chem Biol Drug Des., 90(6), 1307-1311, 2017; Tanaka A. et al.: Cancer Res., 66(1), 419-26, 2006; Lennikov A. et al.: 18, 2586-97, 2012.
Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.
Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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Product ID : SI-5138

Product Name : IMD-0354

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