SynInnova Laboratories Inc.

SI-5836

PLX 4720-d₇, >98% (HPLC)

Isotopic Purity :

98 atom % D

CAS No. :

[1304096-50-1]

Synonyms : N-(4-(5-(4-Chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-3,5-difluorophenyl)propane-1-sulfonamide-d₇

Price and Availability
Pack Size	Price in USD	Quantity	Availability	Shipping Status
5MG	650.00	- +	Back Order	Estimated to Ship on 06.12.2024
10MG	1150.00	- +	Back Order	Estimated to Ship on 06.12.2024

Chemical Properties
Mol. Formula : C₂₃H₁₁D₇ClF₂N₃O₃S	Mol. Weight : 496.96
Appearance : Solid	Melting Point : Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : PLX4720-d7 is the deuterium labelled version analog of PLX4720, which is a potent and selective inhibitor of B-RafV600E with IC50 of 13 nM in a cell-free assay, equally potent to c-Raf-1(Y340D and Y341D mutations), 10-fold selectivity for B-RafV600E than wild-type B-Raf.

References : Tsai J. et al.: Proc Natl Acad Sci U S A, 105(8), 3041-3046, 2008; Paraiso K. H. et al.: Cancer Res., 71(7), 2750-2760, 2011; Nucera C. et al.: Proc Natl Acad Sci U S A 107(23), 10649-10654, 2010.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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Product ID : SI-5836

Product Name : PLX 4720-d₇

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