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SL-2587

O-Deshydroxyethyl bosentan, 98% (HPLC)

CAS No. : 
[174227-14-6]    
MDL No. : 
MFCD25977341
Synonyms : 4-(tert-Butyl)-N-(6-hydroxy-5-(2-methoxyphenoxy)-[2,2'-bipyrimidin]-4-yl)benzenesulfonamide; Bosentan USP related compound B

Price and Availability
Pack Size Price in USD Quantity Availability Shipping Status
5MG120.00 Back Order Estimated to Ship on 06.13.2024
50MG980.00 Back Order Estimated to Ship on 06.13.2024
Chemical Properties
C25H25N5O5S 507.56
Solid Not available
For Laboratory research use only, not for drug, household or other uses.
Applications : O-Deshydroxyethyl bosentan is a metabolite of Bosentan, which is a competitive and dual antagonist of endothelin-1 (ET) for the ETA and ETB receptors with Ki of 4.7 nM and 95 nM in human SMC, respectively.
References : Dhillon S. et al.: Am J. Cardiovasc Drugs 9 (5), 331-350, 2009; Akamata K. et al. Arthritis Res Ther. 16 (2), R86, 2014; Iglarz M. et al. Life Sci. 118 (2), 333-339, 2014; Son G. Y. et al. PLoS One 11(12), e0167713, 2016.
Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.
Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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Product ID : SL-2587

Product Name : O-Deshydroxyethyl bosentan

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