SynInnova Laboratories Inc.

SL-2597

Bosentan USP related compound D, 98%

CAS No. :

[150728-13-5]

MDL No. :

MFCD03839838

Synonyms : 4,6-Dichloro-5-(2-methoxyphenoxy)-2,2’-bipyrimidine

Price and Availability
Pack Size	Price in USD	Quantity	Availability	Shipping Status
1G	50.00	- +	In Stock	Estimated to Ship on 05.17.2024
5G	200.00	- +	In Stock	Estimated to Ship on 05.17.2024

Chemical Properties
Mol. Formula : C₁₅H₁₀Cl₂N₄O₂	Mol. Weight : 349.17
Appearance : Light brown solid	Melting Point : Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : This is an intermediate in the preparation of Bosentan, which is a competitive and dual antagonist of endothelin-1 (ET) for the ET_A and ET_B receptors with Ki of 4.7 nM and 95 nM in human SMC, respectively.

References : Dhillon S. et al.: Am J. Cardiovasc Drugs 9 (5), 331-350, 2009; Akamata K. et al. Arthritis Res Ther. 16 (2), R86, 2014; Iglarz M. et al. Life Sci. 118 (2), 333-339, 2014; Son G. Y. et al. PLoS One 11(12), e0167713, 2016.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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Product ID : SL-2597

Product Name : Bosentan USP related compound D

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